What About the Brain Shrinkage Seen with Aβ Removal?
Anti-amyloid therapy could compromise brain health, a meta-analysis claims. Others say the concern is overblown.
215 RESULTS
Sort By:
Anti-amyloid therapy could compromise brain health, a meta-analysis claims. Others say the concern is overblown.
The microglial receptor activates an antiviral signaling cascade. The virus downregulates TREM2 expression after infecting microglia.
Clusterin latches onto dimers of CD33 on the microglial cell surface, setting off inhibitory signaling that squelched phagocytosis.
At AD/PD, scientists placed more AD genes into microglial pathways, homed in on how TREM2 gets cleaved, debuted TREM2 agonists, and unearthed potential biomarkers.
The antisense oligonucleotide targets extremely rare variants of the superoxide dismutase 1 gene.
Safety and cerebrospinal fluid tau data from the six-month Phase 1 trial are now published.
cGAS and STING initiate a type I interferon response, which weakens neurons’ resilience to tau pathology.
Scientists showed how pooling microglia from different donors, then putting them through cutting-edge analyses, can link genetic variation to functional change.
In Alzheimer’s, Parkinson’s, and Lewy body dementia, phospholipid and cholesterol homeostasis are disrupted early on. Scientists are bringing new methods to bear on the problem.
While memory problems plague some people with lingering COVID symptoms, researchers do not yet understand what is going wrong in their brains.
Data from TRIAD cohort cast activated microglia, egged on by ApoE4, as harbingers of tau pathology and neurodegeneration. Data from BioFinder hint that other microglia restrain these processes.
In sleep-deprived mice, TREM2 signaling activated microglia in a dysfunctional way, hobbling their endolysosomes and keeping them from digesting Aβ plaques.
A deletion in the gene for a lysosomal ion channel popped out of a genomic analysis of LBD risk. So did rare structural variants in other FTD and ALS genes.
One study links early menopause to tangles in early AD, another finds a sex difference in the brain's stress response. Could hormones fuel women’s higher risk of dementia?
The public database includes information about the structure, polarity, and stability of both pathogenic and functional amyloid folds.